Multiple congenital ocular anomalies (MCOA) is an inherited eye disorder that is associated with the silver dilution and is characterized by ocular cysts, enlargement of the cornea, abnormally formed iris/retina, and additional abnormalities.
Pre-implantation genetic diagnosis (PGD) is a procedure used to screen embryos recovered after uterine flush to determine sex and genetic traits through DNA testing prior to implantation in the uterus.
Splashed white is a variable white spotting pattern characterized by a broad blaze, extended white markings on the legs, variable white spotting on the belly, and often blue eyes. Six mutations in two different genes have been shown to cause the splashed white pattern.
The silver dilution dilutes black/brown pigment to lighten the manes and tails of black and bay horses to a flaxen or silver gray. The silver dilution is also associated with an inherited ocular syndrome known as Multiple Congenital Ocular Anomalies (MCOA).