Click here for Price and Turnaround Time
Phenotype: Affected dogs display signs of neurotoxicity following administration of certain drugs, such as ivermectin, acepromazine, loperamide, digoxin, and others. Signs may include tremors, impaired coordination (i.e., ataxia), excess salivation, seizures, slow hear rate (i.e., bradycardia), dilated pupils and respiratory arrest.
Mode of Inheritance: Autosomal recessive
Breeds appropriate for testing: Mixed breed dogs and purebred dogs, particularly of the following breeds: Australian Shepherd, Border Collie, Collie, English Shepherd, German Shepherd, Longhaired Whippet, McNab Shepherd, Miniature Australian Shepherd, Old English Sheepdog, Rough Collie, Shetland Sheepdog, Silken Windhound, Smooth Collie, Wäller, and White Swiss Shepherd.
Explanation of results:
- Dogs with N/N genotype are expected to not have multidrug sensitivity. They cannot transmit this MDR1 variant to any of their offspring.
- Dogs with N/MDR1 genotype will transmit this MDR1 variant to 50% of their offspring. Matings between two carriers of MDR1 may, on average, produce 25% of puppies with multidrug sensitivity.
- Dogs with MDR1/MDR1 genotypes are homozygous for this MDR1 variant and will exhibit multidrug sensitivity even at low doses.