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Phenotype: Dogs with late-onset rcd4-PRA typically start showing signs of visual impairment between 5 and 12 years of age, with an average age of onset of 10 years. Vision loss can progress to complete blindness.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, PRA = Progressive retinal atrophy (rcd4-PRA)
Breeds appropriate for testing: Gordon Setter, Irish Setter, Irish Red and White Setter, English Setter, Australian Cattle Dog, Tibetan Terrier, Polish Lowland Sheepdog, Small Munsterlander, Standard Poodle and Poodle crosses, French Bulldog, Golden Retriever, Dachshund
Explanation of results:
• Dogs with N/N genotype will not have this inherited form of progressive retinal atrophy and cannot transmit this variant to their offspring.
• Dogs with N/PRA genotype will not be affected by this inherited form of progressive retinal atrophy but are carriers. They may transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% rcd4-PRA-affected puppies.
• Dogs with PRA/PRA genotypes are expected to develop this form of progressive retinal atrophy and will transmit this variant to all of their offspring.